这个问题我会，虽然本人英语口语不是很好，但是对英语四六级词汇还是很熟悉的~下面给大家从三个方面具体解释一下：
【含义】
come up意思是：出现，被提出。
come up with意思是：随．．．出现，提出。
一般来说come up（表示被提出）它的主语是事或物。come up with的主语是人。
【用法】
come up走近，被提及，即将到来，突然发生，升起异同之处：come up一般不直接跟宾语，跟宾语时常用与介词with连用。例1：They tend to enjoy the moment when something good is happening, and seize opportunities that come up. (2015年12月四级)他们倾向于享受好事发生的时刻，抓住到来的机会。结构分析：They是主语，tend to enjoy是谓语，the moment是宾语when引导状语从句，something good是主语is happening是谓语,and是连接两个并列成分的连词，seize是谓语，opportunities是宾语，that come up是定语从句。
come up 出现,被提出come up with 随...出现,提出.一般来说,come up （表示被提出）它的主语是事,或物.come up with 的主语是人.比较：The plan came up at the meeting.He came up with the plan at the meeting.
【例句】
come up：
The question is bound to come up at the meeting。会上必然要讨论这个问题。
The car can't come up,as the slope is so steep。坡太陡了，车子上不来。
Slow down a bit and let me come up with you。跑慢一点让我赶上吧。
come up with：
I think you're wrong and you should come up with a better idea。我想你错了，你应该拿出更好的想法。
It took months to come up with an acceptable plan for the banks。过了好几个月才提出银行认为可以接受的计划。
Margaret was the only one who came up with the impressive answer。只有玛格丽特做出了令人佩服并且有力的回答。