这个反应我经常做。
在钯催化下,有机硼化合物与有机卤素化合物进行偶联反应,这就提供了一类常用和有效的合成碳-碳键化合物的方法,我们称之为Suzuki 偶联反应,或Suzuki-Miyaura 偶联反应。
Suzuki 偶联反应的催化循环过程通常认为先是Pd(0)与卤代芳烃发生氧化-加成反应生成Pd(II) 的络合物 1,然后与活化的硼酸发生金属转移反应生成Pd(II))的络合物 2,最后进行还原-消除而生成产物和Pd(0)。
如下图:
例子:
A flask charged with palladium catalyst (0.03 mmol), KOAc (294 mg, 3.0 mmol), and diboron (279 mg, 1.1 mmol) was flushed with nitrogen. DMSO (6 mL) and haloarene (1.0 mmol) were then added. After being stirred at 80 ℃ for an appropriate period, the product was extracted with benzene, washed with water, and dried over anhydrous magnesium sulfate. Kugelrohr distillation in vacuo gave the arylboronates.
这是个经典反应,收率很高,不懂得可以问我。