二者应用场景不同：
1.be interesting to do：做……是有趣的；干……是有趣的；做某事很有趣。
例句：List comper or projects you feel would be interesting to do as part of the activity.
翻译：列出你认为会比较有趣的方案，以作为这次活动的一部分来做。
2.be interesting in doing：对什么感兴趣。
例句：Maybe you do not believe what I said. No problem! Just try to do it, and then keeping do it, finally, you will be interesting in doing it.
翻译：或许你不相信我说的，但是，没关系，只需要先尝试去做，然后再坚持做下去，最后你会发现，你对此非常感兴趣。
扩展资料：
be interesting to do 和be interesting in doing可以相互替代和不可相互替代的场景：
1.不可相互替代的场景：
表示对所知的事情或所做的事情的感情反应时，be interested to do不能用 be interested in doing 来代替，如：I was interested to read in the paper that scientists have found out how to talk to whales.
2.可相互替代的场景：
表示愿意知道、听到、看到、学到某事时，be interested to do可以用 be interested in doing 来代替，如：I will be most interested to hear your personal views on the station there.
参考资料：百度百科-动名词