I will try my best to do the issue of responsibility well (try one's to do sth.) i will do as hard as i can to finish the issue of responsibility well (do as hard as sb. can) it is certain that i will devote myself to doing the issue of responsibility (it is certain + that clause) i do will try my best to do the issue of responsibility well (强调句) (本职工作我翻译为the issue of responsibility ,如果你觉得不合适或者不符合语境可以用 take responsibility to do sth 来说)